Synadrene VS Synadrex Supplement Comparison

Synadrene VS Synadrex Supplement Comparison

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Synadrene VS Synadrex

For years, Metabolic Nutrition Synedrex has been one of the most legendary thermogenics and energy products the industry has seen. Having undergone a reformulation before being temporarily pulled by Metabolic Nutrition, anyone that is familiar known the power of Synedrex knows that it’s no joke and a powerhouse of a supplement. In light of the latest hiatus from the market, Hi Tech has once again done their trend of playing it dangerously close in terms of creating a copycat product that is almost identical in name and formula with a few alterations to improve upon the original, much like they did with Jack’d Up and Hydroxylite Pro, both of which are USPLabs product clones.

Their latest venture Synadrene was designed to embody everything that users loved about the original Metabolic Nutrition Synedrex, and with improvements through slight modifications of the ingredients, it is poised to be more powerful than ever. On paper, it appears to be a “best of both worlds” hybrid between the original Synedrex (with DMAA) and the second Synedrex formulation (AMP Citrate).

Here’s a breakdown of the ingredients used in both Metabolic Nutrition Synedrex and the new version of Hi Tech Synadrene, both featuring the resurging DMAA:

Methylxanthine (Caffeine)

  • Potent CNS stimulant that antagonizes adenosine receptors
  • Enhances mental focus and energy
  • Increase cognition and reaction time
  • Contributes to fat loss by helping release more fat cells and reduces fat storage


  • Also known as bitter orange extract
  • Helps facilitate utilization of energy substrates
  • Helps stimulate metabolic processes and favors uptake of amino acids into muscle
  • May help suppress appetite
  • Stimulates fat loss and energy expenditure

Green Tea Extract

  • Shown to aid in inducing lipolysis (fat breakdown)
  • High polyphenol and catechin content offer numerous health benefits
  • Effects further amplified when combined with caffeine
  • Synadrene’s green tea content: 45% EGCG/75% total catechins/95% polyphenols


  • Synthetic molecule consisting of two Thiamine (Vitamin B1) molecules
  • May help alleviate feelings of fatigue
  • Promotes mental clarity and cognitive focus
  • Aids in countering mental fog from dieting

DMAA (1,3 Dimethylamylamine)

  • Powerful neural stimulant with structure similar to ephedrine and adrenaline
  • Classified as sympathomimetic amine extracted from Geranium
  • Triggers the release of norepinephrine – Creates ‘euphoric’ sensation
  • May also provide appetite suppression effects

Yohimbine Extract

  • Increases adrenaline levels in the body
  • Stimulates Alpha receptors to help trigger fat loss
  • May help reduce body fat in ‘trouble areas’
  • Reduces hunger sensation

Alpha Lipoic Acid

  • Mithochondrial fatty acid involved in energy metabolism
  • Synthesized in the body naturally; beneficial against inflammation and oxidation
  • Shown to be protective against heart disease, diabetes and neurological disease
  • Potent anti-oxidant compound properties
  • Has glucose partitioning effects via Glut-4 activation

Sandalwood Extract

  • Source of pterostilbene
  • Shown to have anti-diabetic properties; aids in glucose disposal
  • May help improve memory and cognition

Poly Thyronine

  • Naturally occurring metabolite of the thyroid hormone T2
  • Elevates basal metabolic rate for more calorie burning
  • Acts as appetite suppressant
  • Shown to not effect heart rate or blood pressure
Hydroxyelite vs Oxyelite Pro
Related: Click above to see our Hydroxyelite VS Oxyelite comparison.

As you can see, the ingredient profiles are very, very well thought out and thorough. One key difference is that Hi Tech said that they left out the BMPEA, claiming that there wasn’t an efficacious dose of it used in the original. However it is more likely that they didn’t include it because of the removal of it from the market by the FDA, but we all know how Hi Tech is known for fighting the good fight in that regard as we have seen with them reintroducing DMAA.

In regards to the DMAA controversy, let’s first take a look at exactly what it is. DMAA technically has a chemical structure similar to that of amphetamine. Now, while it is not believed to have stimulant effects as strong as amphetamine, it works in a similar way by temporarily increasing mental alertness, speeding up heart rate and causing vasoconstriction which may increase blood pressure and risk of cardiovascular events.

DMAA, much like many other of the ‘new age’ stimulants that have surfaced over recent years, was actually first used in 1944 as a patented medication for nasal congestion, but later taken off the consumer market. Following the banning of ephedra in 2005, DMAA was reintroduced as a supplement for central nervous system stimulation.

The issue is there is an ongoing debate, and even lawsuit between the FDA and Hi Tech Pharmaceuticals on whether or not it was ever formally banned. The issue arises from the controversy of whether or not DMAA which was introduced by the drug company Eli Lily in the 1940’s is in fact a natural constituent of geranium as claimed by supplement manufacturers or a synthetic compound. It will be interesting to see how it plays out, but for now, it looks like DMAA isn’t going anywhere which is good news for those who like the effects as it is a very effective ingredient.

So there you have it! If you were a fan of the original Metabolic Nutrition Synedrex, then Hi Tech Pharmaceuticals has answered the call with the introduction of Synadrene with what are noted to be ‘improvements’ over the legendary original formula. Controversy or not, Synadrene has arrived and you can enjoy the power of this legendary thermogenic formula!

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  1. I am a faithful user of Metabolic’s Synadrex and am happy to know I have something to use when I run out of it! Thanks for the info!!

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