OR1GIN helps to increase appetite and helps your body utilize the extra calories in the most efficient manner, mainly in the form of skeletal muscle. OR1GIN performs those two functions via ghrelin secretion and ribosome biogenesis. It would be a perfect addition to a pro-hormone cycle or to use as part of a post-cycle therapy (PCT) to maintain your gains. OR1GIN will deliver a significant boost in muscle anabolism. By stimulating ghrelin secretion and ribosome biogenesis, OR1GIN will increase appetite, energy metabolism and muscle hypertrophy.
Ghrelin is an endogenous ligand, GHS-R1a, of the growth hormone secretagogue receptor that can cause a significant increase in appetite. It is the only hormone that exhibits this appetite enhancement, or orexigenic effect, following peripheral administration. It also stimulates growth hormone secretion, gastric motility, and gastric acid secretion, as well as induction of a positive energy balance.
The ribosome is a nucleoprotein particle responsible for one of the key processes in every cell, the decoding of messenger ribonucleic acid (mRNA) into protein. mRNA is a set of RNA molecules that translate genetic information from DNA to the ribosome. The biogenesis of ribosomes is a tightly regulated activity and it is inextricably linked to other fundamental cellular processes, including growth, or muscle hypertrophy, and cell division as the studies below demonstrate.
The GHrow matrix contains of 750mg of Hesperidin Methyl Chalcone, 600mg of Gentian Root extract, 300mg of Robuvit, and 300mg of Actractylodes Chinesis.
Hesperidin is a flavanone glycoside or a sugar molecule consisting of the flavone hesperitin bound to the disaccharide rutinose. It is naturally occurring in citrus fruits including oranges, tangerines and grapefruits. It has been shown to influence several biological functions, including inhibiting tumor development and the proliferation of human cancer cells, as well as the destruction of cancer cells. It also has antibacterial, antiviral, and antifungal properties. It can also play a role in ghrelin secretion from the stomach through antagonism of the serotonin receptors.
Gentian root is a herbal bitter that is derived from the perennial, Gentiana lutea L. It has traditionally been used in the treatment of digestive disorders and is an ingredient of many proprietary medicines. It is known to have several biological effects, such as anti-oxidant, anti-tumor and hepatoprotective properties. The increase in appetite that it provides can be attributed to its ability to stimulate ghrelin secretion.
Robuvit is an extract from French oak wood (Quercus robur) that is rich in roburins and other flavonoids. It is typically used to improve liver dysfunction and chronic fatigue. It also may reduce muscle soreness, accelerate recovery and induce changes in the function of the cellular protein factories called ribosomes. Defective ribosomal function has shown to be associated with several diseases such as chronic fatigue syndrome (CFS).
Atractylodin is a derivative of the Atractylodes herb, a member of the Asteraceae family. There are three different species: Atractylis lancea (Thunb.). DC., Atractylodes japonica Koidz.ez Kitam and Atractylodes chinesis (DC.) koidz. It has been traditionally used as treatment for several conditions including diarrhea, atrophy and flaccidity, arthralgia (joint pain) due to wind and dampness and loss of appetite. The appetite increase from Atractylodin is indicative of ghrelin secretion.
ORIG1N Supplement Facts